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หมวดหมู่ : 3. Protein & Enzyme ,  Recombinant protein ,  Servicebio , 
แบรนด์ : Servicebio
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DESCRIPTION | ||
Gene Name Synonym | IL-2, TCGF, lymphokine, Interleukin 2 | |
Species | Rat | |
Accession | P17108 | |
Source | HEK293 cells | |
SPECIFICATIONS | ||
Amino acid sequence | Ala21-Gln155 is expressed with a 10×His tag at the C terminus | |
Molecular Weight | 16.9 kDa | |
Purity | >95.0% as determined by SDS-PAGE | |
Endotoxin | <5 EU mg-1 | |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. | |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. | |
STORAGE | ||
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. | |
BACKGROUND | ||
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell growth factor essential for the proliferation of T cells and the generation of effector and memory cells. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. IL-2 promotes the generation, survival, and functional activity of Tregcells. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in linical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. | ||
Data | ||
SDS-PAGE | Bioactivity | |
Active Recombinant Rat IL-2 Protein was determined by SDS-PAGE with Coomassie Blue. | Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is 0.5-5 ng/mL. |
For Research Use Only!
Ver. No.: V1.0-202102