CXCL5 (8-78 a.a.), Human, 5 ug

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Chemokine (C-X-C motif) Ligand 5 (CXCL5)
Epithelial-derived Neutrophil Activating Peptide 78 (ENA78, ENA-78)
Lipopolysaccharide (LPS) Induced CXC Chemokine (LIX)
Small Inducible Cytokine Subfamily B Member 5 (SCYB5)

CXCL5 is an ELR type of CXC chemokine. It is expressed in various epithelial cell lines alongside CXCL8 (IL8) and CXCL1 in response to stimulation by IL1 or TNF-alpha. It is down regulated by IFN-gamma. Like many CXC chemokines, CXCL5 is a ligand for CXCR2. It is a chemoattractant and activator of neutrophils, and plays a role in angiogenesis and inflammation, as well as the metastasis of various cancers. It also blocks insulin signaling by activating the JAK2/STAT5/SOCS2 pathway. The truncated form of CXCL5 (8-78 a.a.) has been reported as being 3-fold more potent than the full length protein (1-78 a.a.).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source:Escherichia coli

MW: ~7.8 kDa (71 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 10-100 ng/ml.

Storage/Handling: Store desiccated at -20°C.

HGNC: 10642

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

https://www.goldbio.com/product/6277/cxcl5-8-78-aa-human