IL5, Human

PRODUCT DESCRIPTION
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Interleukin 5
Colony-Stimulating Factor, eosinophil
Eosinophil Differentiation Factor, EDF
T-cell Replacing Factor, TRF

The IL5 gene is located on chromosome 5 in humans, in close proximity to the genes encoding IL3, IL4, and granulocyte-macrophage colony-stimulating factor (CSF2), which are often co-expressed in TH2 cells. Through binding to the IL5 receptor, IL5 stimulates B cell growth and increases immunoglobulin secretion and is also a key mediator in eosinophil activation. Interleukin 5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. Human IL5 is 115 amino acids long (murine IL5 has 133 amino acids) and is a TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely IL3 and CSF2), this glycoprotein is a homodimer in its active form.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~26.5 kDa (2x 116 amino acids)

Purity: >98% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0×107 IU/mg.

Storage/Handling:Store desiccated at -20°C.

HGNC: 6016

NOT FOR HUMAN USE!

Additional resources for this protein may be found at: OMIM