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หมวดหมู่ : 3. Protein & Enzyme ,  Recombinant protein ,  Servicebio , 
แบรนด์ : Servicebio
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DESCRIPTION | ||
Gene Name Synonym | IL-9, Interleukin-9, IL9, Cytokine P40 | |
Species | Mouse | |
Accession | P15247 | |
Source | HEK293 cells | |
SPECIFICATIONS | ||
Amino acid sequence | Gln19-Pro144 is expressed with a 10×His tag at the C terminus | |
Molecular Weight | 15.6 kDa | |
Purity | >95.0% as determined by SDS-PAGE | |
Endotoxin | <5 EU mg-1 | |
Formulation | Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. | |
Reconstitution | Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. | |
STORAGE | ||
Stability and Storage | 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. | |
BACKGROUND | ||
Interleukin 9, also known as IL-9, is a cytokine (cell signaling molecule) belonging to the group of interleukins. IL-9 is a multifunctional cytokine secreted by TH2 lymphocytes. Interleukin-9 is reported to play important roles in innate and adaptive immunity in extrarenal inflammatory diseases. The tolerogenic cytokine IL9 promotes T regulatory cell function and allergic airway inflammation. Eliminating endogenous IL9 enabled sensitization of host T cells to tumors, leading to their early rejection without the requirement of vaccines or immunomodulatory therapies. IL-9 predominantly produced by TH17 cells synergizes with TGF-β1 to differentiate naive CD4+ T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. | ||
Data | ||
SDS-PAGE | Bioactivity | |
Recombinant Mouse IL-9 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at30-40 kDa. | Measured in a cell proliferation assay using MC/9 mouse mast cells. The ED50 for this effect is 1-5 ng/mL. |
For Research Use Only!
Ver. No.: V1.0-202102