IL1RN (IL-1RA), Equine, 5 ug

PRODUCT DESCRIPTION
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Equine Interleukin-RN
Interleukin 1 Receptor Antagonist (IL1RN)
EqIL1RA
Interleukin 1-RN
IL1-RN

IL1RN, initially called the IL1 inhibitor, is encoded by the IL1RN gene which is a member of the interleukin 1 cytokine family. IL1RN is secreted by various types of cells, including immune cells, epithelial cells and adipocytes. IL1RN functions to inhibit the activity of interleukin-1 by binding to the IL1R1 receptor, which prevents it from associating with the co-receptor IL1RAP. IL1RN is also used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL1 plays a key role. The Equus caballus IL1RN is a single nonglycosylated polypeptide chain that has been shown to block the inflammatory responses induced by IL1 both in vitro and in vivo. The protein shows 26% amino acid homology to IL1β and 19% homology to IL1α.

Sterile Filtered White Lyophilized Powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~17.4 kDa (152 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.

NOT FOR HUMAN USE!

NCBI: 100034236

Additional resources for this protein may be found at: OMIM